Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially...

• Get to know the background of DevOps so you understand the collaboration between different aspects of an IT organization and a software developer
• Improve your organization's performance to ensure smooth production of software and services
• Deploy top-quality software and...

Discover how to implement and operate in an Agile manner at every level of your enterprise and at every point from idea to delivery. Learn how Agile-mature organizations adapt nimbly to microchanges in market conditions. Learn cutting-edge practices and concepts as you extend your implementation of Agile through the entire enterprise to meet...

The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological...

Epidemiological studies have estimated that approximately 35 percent of cancers are potentially avoidable by nutritional modification. These modifications include strategies such as caloric restriction and limitation of specific macro-nutrient groups. However, recent research indicates that what you eat may well be just as important as what...

Illuminating a hidden and fascinating chapter in the history of globalization, Paul Gootenberg chronicles the rise of one of the most spectacular and now illegal Latin American exports: cocaine.

Gootenberg traces cocaine's history from its origins as a medical commodity in the nineteenth century to its repression during...

Bottlenecks: Aligning UX Design with User Psychology fills a need for entrepreneurs, designers, and marketing...

In the flow of drugs to the United States from Latin America, women have always played key roles as bosses, business partners, money launderers, confidantes, and couriers―work rarely acknowledged. Elaine Carey’s study of women in the drug trade offers a new understanding of this intriguing subject, from women drug smugglers in the...

It is well-known that the daily diet plays an important role in the preservation and integrity of renal function in patients with chronic kidney disease. However, there currently exists some confusion as to the right diet because of the MDRD (Modification of Diet in Renal Disease) study, which has shown that a low-protein diet does not have a...

A collection of cutting-edge methods for investigating G protein signaling from a variety of perspectives ranging from in vitro biochemistry to whole animal studies. Among the readily reproducible techniques presented are those for the purification of G proteins and effectors enzymes, assays of these purified G proteins and effector enzymes,...