Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially...
The catecholamine dopamine (DA) plays a key role in the physiology of most vertebrate and invertebrate organisms. In addition to its role as a transmitter in the nervous system, it has a role in development. The relatively few DA neurons in the mammalian brain have important roles in many neural functions including fine motor integration,...
The prostate hosts neuroendocrine cells whose origin and functional roles warrant better understanding. These cells synthesize and deliver a number of neurosecretory substances having regulative activities over growth, cell differentiation, and secretion, and might influence the development of proliferative disorders such as hyperplasia or...
Stephen P. Ethier and a panel of leading investigators comprehensively analyze the cellular, molecular, and endocrine factors in the development of cancers of the breast, prostate, endometrium, and ovary. Concentrating on defining the most important unresolved issues in the field, the authors review how steroid hormones function to regulate...
Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!
This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory...
Clusterin is a multifunctional protein which was independently discovered by more than ten different research groups in the 1980s. New roles of clusterin in brain functions have come to llight which are summarized here by the researchers involved. Recent discoveries include a unique lipoprotein particle containing clusterin and apoE secreted...
Recent research and clinical work have demonstrated that the rapid urologic innovation in minimally invasive treatment is creating exciting new horizons in endourology. This sixth volume in the series Recent Advances in Endourology brings that knowledge to a wider audience, focusing on the new concept of endourooncology, which is the...
Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular...
Collagenases are an important subfamily of matrix metalloproteinases utilizing native collagens as a substrate. This book reviews a current knowledge of the structures and functions of collagenases and the roles they play in development, tumor metastasis, and tissue remodeling during wound healing. This review comes at a time when new...
Executive teams are a key ingredient of today's business world--from the charismatic CEO who relies on the operational expertise of a COO, to family businesses which trust in personal bonds to achieve professional results. This study examines duo and trio executive teams in practice to shed light on the personalities, relationships, and...
Microsoft's new version of the MCSA certification for Windows Server 2012 R2 requires passing three exams (or one Upgrade exam if you have your MCSA or MCITP in Windows Server 2008). This value-priced study guide includes more than 1,000 pages of quality exam-prep...
A cutting-edge collection of readily reproducible techniques for the isolation, culture, and study of activation and signaling in human mast cells. These methods take advantage of the latest advances in molecular biology, technology, and information science. They include methods for the identification of mast cells, the development of mast...
