Completely revised and expanded from four to five volumes, this new edition of the Handbook of Parenting appears at a time that is momentous in the history of parenting. Parenting and the family are today in a greater state of flux, question, and redefinition than perhaps ever before. We are witnessing the emergence of striking...
Completely revised and expanded from four to five volumes, this new edition of the Handbook of Parenting appears at a time that is momentous in the history of parenting. Parenting and the family are today in a greater state of flux, question, and redefinition than perhaps ever before. We are witnessing the emergence of striking...
Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!
This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory...
Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially...
The catecholamine dopamine (DA) plays a key role in the physiology of most vertebrate and invertebrate organisms. In addition to its role as a transmitter in the nervous system, it has a role in development. The relatively few DA neurons in the mammalian brain have important roles in many neural functions including fine motor integration,...
The prostate hosts neuroendocrine cells whose origin and functional roles warrant better understanding. These cells synthesize and deliver a number of neurosecretory substances having regulative activities over growth, cell differentiation, and secretion, and might influence the development of proliferative disorders such as hyperplasia or...
Stephen P. Ethier and a panel of leading investigators comprehensively analyze the cellular, molecular, and endocrine factors in the development of cancers of the breast, prostate, endometrium, and ovary. Concentrating on defining the most important unresolved issues in the field, the authors review how steroid hormones function to regulate...
Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular...
Executive teams are a key ingredient of today's business world--from the charismatic CEO who relies on the operational expertise of a COO, to family businesses which trust in personal bonds to achieve professional results. This study examines duo and trio executive teams in practice to shed light on the personalities, relationships, and...
Collagenases are an important subfamily of matrix metalloproteinases utilizing native collagens as a substrate. This book reviews a current knowledge of the structures and functions of collagenases and the roles they play in development, tumor metastasis, and tissue remodeling during wound healing. This review comes at a time when new...
The tumor necrosis factor/receptor [TNF/TNFR] superfamily consists of more than 20 transmembrane proteins with conserved N-terminal cysteine-rich domains [CRDs] in the extracellular ligand binding region. Members have wide tissue distribution and play important roles in biological processes such as lymphoid and neuronal development, innate...
