The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens?
Ready to take your ebooks to the next level with EPUB 3? This concise guide includes best practices and advice to help you navigate the format’s wide range of technologies and functionality. EPUB 3 is set to turn electronic publishing on its head with rich multimedia reading experiences and scripted interactivity, but this...
The discussion about the manned spacecraft program was initiated at NASA in 1959.
Only one year later, Dr. Kalman and Dr. Schmidt linked the linear Kalman filter and the
perturbation theory in order to obtain the Kalman-Schmidt filter, currently known as the
extended Kalman filter. This approach would be implemented in 1961 using an...
Learn how to set up Nagios 4 in order to monitor your systems efficiently About This Book Set up, configure, and manage Nagios 4 to secure and monitor your system Learn how to use libnagios and NERD to process and handle queries Packed with lots of tips, tricks and illustrations to explain the Nagios configuration and monitoring concepts in a...
Approximate Global Convergence and Adaptivity for Coefficient Inverse Problems is the first book in which two new concepts of numerical solutions of multidimensional Coefficient Inverse Problems (CIPs) for a hyperbolic Partial Differential Equation (PDE) are presented: Approximate Global Convergence and the Adaptive Finite Element...
This book provides new insights on the study of global environmental changes using the ecoinformatics tools and the adaptive-evolutionary technology of geoinformation monitoring. The main advantage of this book is that it gathers and presents extensive interdisciplinary expertise in the parameterization of global biogeochemical cycles and...
Service-Oriented Applications and Architectures (SOAs) have captured the interest of industry as a way to support business-to-business interaction, and the SOA market grew by $4.9 billion in 2005. SOAs and in particular service-oriented computing (SOC) represent a promising approach in the development of adaptive distributed systems. With...
The importance of accuracy verification methods was understood at the very beginning of the development of numerical analysis. Recent decades have seen a rapid growth of results related to adaptive numerical methods and a posteriori estimates. However, in this important area there often exists a noticeable gap between mathematicians creating...
Over a century ago, William James proposed that people search through memory much as they rummage through a house looking for lost keys. We scour our environments for territory, food, mates, and information. We search for items in visual scenes, for historical facts, and for the best deals on Internet sites; we search for new friends to add...
This graduate-level textbook introduces fundamental concepts and methods in machine learning. It describes several important modern algorithms, provides the theoretical underpinnings of these algorithms, and illustrates key aspects for their application. The authors aim to present novel theoretical tools and concepts while giving concise...
Traditional methods for creating intelligent computational systems have privileged private "internal" cognitive and computational processes. In contrast, Swarm Intelligence argues that human intelligence derives from the interactions of individuals in a social world and further, that this model of...
Oracle SQL Tuning with SQLTXPLAIN is a practical guide to SQL tuning the way Oracle's own experts do it, using a freely downloadable tool called SQLTXPLAIN. Using this simple tool you'll learn how to tune even the most complex SQL, and you'll learn to do it quickly, without the huge learning curve usually associated with...
