Several years ago, when the discovery of catalytic RNA was recognized in a public manner, many people asked if new ?elds of therapy would soon be available. Although some tentative positive answers were given, nobody would say with certainty that RNA of various kinds was a truly promising means of altering gene expression. In fact, over the...

The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum...

“This is a must read for all startups and stakeholders.”
— Steve Blank, author of The 4 Steps to the Epiphany, creator of Customer Development methodology

“The Entrepreneur’s Guide is an easy read. It is written in a conversational tone, doesn’t take itself too...

This book highlights proteasome structures and how they are related to different aspects of proteasome function. Moreover, the book reports on the functional roles these highly developed proteolytic machines play within the cell. It was a great surprise to the scientific world that proteolysis provides crucial functions in cellular...

You already know social media can help you find customers, strengthen relationships, and build your...

"For beginners and professionals in search of answers." -- Stephen Joel Trachtenberg, President Emeritus and University Professor of Public...

This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer's original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the...

The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists which are...

Our understanding of how the human brain performs mathematical calculations is far from complete, but in recent years there have been many exciting breakthroughs by scientists all over the world. Now, in The Number Sense, Stanislas Dehaene offers a fascinating look at this recent research, in an enlightening exploration of the...

Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models...