Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport,...

This book offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description...

In Tumor Targeting in Cancer Therapy, Dr. Michel Pagé and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors...

Since its discovery in 1957, Coenzyme Q has piqued the interest of scientists from a wide range of disciplines because of its bioenergetics, vitamin-like behavior, and interactions with antioxidant vitamins E and C. Coenzyme Q: Molecular Mechanisms in Health and Disease is a comprehensive treatise on this often-studied coenzyme. International...

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. With the discovery of key mechanisms that are involved in mediating PCD and in promoting resistance to therapy, design of therapeutic approaches for promoting tumor-selective cell death has risen dramatically....

Linux Malware Incident Response is a "first look" at the Malware Forensics Field Guide for Linux Systems, exhibiting the first steps in investigating Linux-based incidents. The Syngress Digital Forensics Field Guides series includes companions for any digital and computer forensic investigator and analyst. Each book is...

It has become clear to researchers in robotics and adaptive behaviour that current approaches are yielding systems with limited autonomy and capacity for self-improvement. To learn autonomously and in a cumulative fashion is one of the hallmarks of intelligence, and we know that higher mammals engage in exploratory activities that are not...