In the past, many tumor marker laboratory tests have not been sensitive enough for the very early detection of cancer. However, many of them have nonetheless proved useful in monitoring therapy, following the course of the tumor, and predicting prog­ nosis. Today, cancer may be viewed as a genetic disease with various specific chromo­...

Expert laboratorians update the classic bioconjugation methods and introduce valuable new techniques that go beyond pure biomedical applications to include elements from advanced organic synthesis, molecular biology, and materials science. These readily reproducible methods cover the preparation of protein conjugates using covalent and...

A diverse team of researchers, technologists, and engineers describe, in simple and practical language, the major current and evolving technologies for improving the biocatalytic capabilities of mammalian, microbial, and plant cells. The authors present state-of-the-art techniques, proven methods, and strategies for industrial screening,...

Thanks to recent advancements, optimization is now recognized as a crucial component in research and decision-making across a number of fields. Through optimization, scientists have made tremendous advances in cancer treatment planning, disease control, and drug development, as well as in sequencing DNA, and identifying protein...

What is the basic nature of the modern computer? How does it work? How has it been possible to squeeze so much power into increasingly smaller machines? What will the next generations of computers look like? In this Very Short Introduction, Darrel Ince looks at the basic concepts behind all computers, the changes in hardware and...

These proceedings contain the papers presented at the 5th Annual Genetic and Evolutionary Computation Conference (GECCO 2003). The conference was held in Chicago, USA, July 12–16, 2003.

A total of 417 papers were submitted to GECCO 2003. After a rigorous doubleblind reviewing process, 194 papers were accepted for full...