Although depression is the most common presentation of bipolar disorder, correct diagnosis generally requires a history of mania and thus presents a formidable challenge. This book provides clinicians with the necessary guidance to distinguish this illness and pursue an appropriate therapeutic course. It brings together a team of clinical...

The definitive story of the international modeling business—and its evil twin, legalized flesh peddling—Model is a tale of beautiful women empowered and subjugated; of vast sums of money; of sex and drugs, obsession and tragic death; and of the most unholy combination in commerce: stunning young women and rich, lascivious...

The wealth of insights into the brain’s functioning gained by neuroscience in recent years led to the development of new possibilities for intervening in the brain such as neurotransplantation, neural prostheses and brain stimulation techniques. Moreover, new and safer classes of psychopharmaceutical drugs lend themselves to...

This volume reviews advances in cancer chemotherapy research over the last 10 years. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs. Each chapter covers the drug target and biological rationale, chemotypes, clinical status and future prospects in this...

This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as...

This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. It elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components. The book contains up-to-date information about the chromatin structure and chromatin related diseases and drug...

Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These...

This timely and original handbook paves the way to success in plant-based drug development, systematically addressing the issues facing a pharmaceutical scientist who wants to turn a plant compound into a safe and effective drug. Plant pharmacologists from around the world demonstrate the potentials and pitfalls involved, with many of the...

THE NEW YORK TIMES BESTSELLER

Three former CIA officers--among the world's foremost authorities on recognizing deceptive behavior--share their proven techniques for uncovering a lie

Imagine how different your life would be if you could tell whether someone was lying or telling you the truth....