Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These...

Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including...

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Three former CIA officers--among the world's foremost authorities on recognizing deceptive behavior--share their proven techniques for uncovering a lie

Imagine how different your life would be if you could tell whether someone was lying or telling you the truth....

It is currently estimated that approximately 41 million people in the United States have a musculoskeletal condition. Of these, more than 50% have some limitation of functional activity and many have to stop work entirely. Musculoskeletal and rheumatic symptoms account for about 15% of physician visits. The purpose of this manual is to...

The two editors from academia and a major pharmaceutical company have assembled an experienced,...

Since the first edition of Identification of Pathogenic Fungi, there has been incredible progress in the diagnosis, treatment and prevention of fungal diseases: new methods of diagnosis have been introduced, and new antifungal agents have been licensed for use. However, these developments have been offset by the emergence of resistance...

We are currently experiencing a fundamental shift in the way in which we approach the characterization of cancer. Never before has the make up of cancer tissues and individual cells been so exhaustively researched and char- terized. We are now capable of producing molecular “fingerprints” that ch- acterize the expression of all...

This two volume set contains frank and factual information about symptoms, causes, effects, prevention, and treatment of substance abuse—alcohol, nicotine, and drugs—and of behavioral addictions such as eating disorders, pathological gambling, and compulsive sexual activity. Including the most up-to-date research, the addiction...

There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental...

This revised edition has been completely updated and expanded to address the latest developments and professional concerns in forensic medicine. There are new chapters on the medical aspects of police restraint and new material on the potential of police exposure to infection, the role of alcohol and drugs in vehicular accidents, and forensic...