This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as...

Evidenced by the success of Facebook, Twitter, and LinkedIn, online social networks (OSNs) have become ubiquitous, offering novel ways for people to access information and communicate with each other. As the increasing popularity of social networking is undeniable, scalability is an important issue for any OSN that wants to serve a large...

This fully updated and dramatically expanded edition will allow family physicians and specialists to fully understand not only what they need to do, but also why. New to this edition-over half the book-are discussions of the clinical guidelines for selecting patients for densitometry measurements, various questionnaires and indices that have...

When you design a page for print, you control the size of the paper and the placement of the elements. But...

Load and Resistance Factor Design (LRFD) and Load and Resistance Factor Rating (LRFR) are design and evaluation methods that have replaced or offered alternatives to other traditional methods as the new standards for designing and load-rating...

This wickedly inventive guide explains how to design and build 15 fiendishly fun electronics projects. Filled with photos and illustrations, 15 Dangerously Mad Projects for...

Building a culture of purpose is one of the greatest challenges facing modern leaders, as today's best minds are looking for meaning, not just jobs. More than any other single factor, cultures of purpose power winning organizations,...

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the...

In contemporary globally competitive markets, the development of new products is considered a critical success factor for organizations. Significant efforts have been invested in the development of methods and tools for improving the management of design processes, being a key element in development processes, especially those related...

This book contains a series of contributions from internationally renowned academics with special expertise in one or other diseases which collectively are grouped under the heading myeloproliferative disorders. There have been many recent developments in understanding the pathophysiology and a number therapeutic innovations in this area. A...

Modeling atmospheric processes in order to forecast the weather or future climate change is an extremely complex and computationally intensive undertaking. One of the main difficulties is that there are a huge number of factors that need to be taken into account, some of which are still poorly understood. The Factor Separation (FS) method is...