Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models...

Modern cardiovascular science has produced a revolutionary new idea: the heart acts not merely as a pump, but as a "gland", that is as a regulator of circulatory homeostasis and salt-water balance. This book combines the classical heamodynamic view with the new neuro-hormonal paradigm, in all its potential clinical implications. The...

You Are Not Alone

Being an entrepreneur is scary. From late payments to bank crisis, often the future of your business rides on one crucial decision--one you have to make all on your own.
But it doesn't have to be that way. Others have faced the same problems, and for the first time have gathered to share their...

Considerable evidence indicates that the U.S. is falling behind when it comes to innovation. In part, this shift stems from the globalization of research and the advancement of other nations. But, it also arises from a widespread failure to adapt to the competitive environment generated by the evolution of science and technology.
The...

An emergent approach to organizational strategy making assumptions that few organizations actually realize the goal of deliberative, top-down strategic planning, and that effective strategy making occurs on a continual basis and is a shared activity of the entire organization. This innovative book provides the first in-depth look at how real...

• Create highly scalable applications and services using the Linux container virtualization paradigm
• ...

• Analyze Big Data sets, create attractive visualizations, and manipulate and process various data types
• Packed with rich recipes to help you learn and explore amazing algorithms for statistics and machine learning
• Authored by Ivan Idris, expert in python programming and proud...

Now diffused among end-user devices in mobile and wireline networks, the "cloud" is becoming the "fog." This book focuses on the challenges and solutions related to cloud and fog computing for 5G mobile networks and presents novel approaches to the frameworks and schemes that carry out storage, communication, computation,...

Going beyond mere theory and marketing hype, Eberhard Wolff presents all the knowledge you need to capture the full benefits of this emerging paradigm. He illuminates...

• A highly practical guide filled with numerous examples unleashing the power of design patterns with Go.
• Discover an introduction of the CSP concurrency model by explaining...

In the early 1990s, almost 200 yr after Edward Jenner demonstrated the effectiveness of the smallpox vaccine, a new paradigm for vaccination emerged. The conventional method of vaccination required delivery of whole pathogens or structural subunits, but in this new approach, DNA or genetic information was administered to elicit an...

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the...