DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for...
This book features challenging problems of classical analysis that invite the reader to explore a host of strategies and tools used for solving problems of modern topics in real analysis. This volume offers an unusual collection of problems — many of them original — specializing in three topics of mathematical analysis: limits,...
Following the pioneering discovery of alpha clustering and of molecular resonances, the field of nuclear clustering is today one of those domains of heavy-ion nuclear physics that faces the greatest challenges, yet also contains the greatest opportunities. After many summer schools and workshops, in particular over the last decade, the...
This book constitutes the thoroughly refereed post-conference proceedings of the 9th International ICST Conference on Mobile and Ubiquitous Systems: Computing, Networking, and Services, MobiQuitous 2012, held in Beijing, China, Denmark, in December 2012. The revised full papers presented were carefully reviewed and selected from numerous...
This volume offers very selected papers from the 2014 conference of the “International Association for Computing and Philosophy” (IACAP) - a conference tradition of 28 years. The theme of the papers is the two-way relation between computing technologies and philosophical questions: Computing technologies both raise new...
Support Vector Machines: Optimization Based Theory, Algorithms, and Extensions presents an accessible treatment of the two main components of support vector machines (SVMs)âclassification problems and regression problems. The book emphasizes the close connection between optimization theory and SVMs since optimization is...
This is the first comprehensive book dedicated entirely to the field of decision trees in data mining and covers all aspects of this important technique.Decision trees have become one of the most powerful and popular approaches in knowledge discovery and data mining, the science and technology of exploring large and complex bodies of data in...
An invaluable tool in Bioinformatics, this unique volume providesboth theoretical and experimental results, and describes basicprinciples of computational intelligence and pattern analysis whiledeepening the reader's understanding of the ways in which theseprinciples can be used for analyzing biological data in anefficient manner.
Explore functional programming and discover new ways of thinking about code. You know you need to master functional programming, but learning one functional language is only the start. In this book, through articles drawn from PragPub magazine and articles written specifically for this book, you'll explore functional...
Social networks provide a powerful abstraction of the structure and dynamics of diverse kinds of people or people-to-technology interaction. Web 2.0 has enabled a new generation of web-based communities, social networks, and folksonomies to facilitate collaboration among different communities.
As little as two decades ago, deliberately injecting botulinum toxin into patients would have seemed foolhardy at best and criminal at worst. The increased clinical use of botulinum toxins has expanded the body of knowledge available on the structure and function of these proteins. This knowledge can be applied to topics as varied as...
The prominence of the Bupleurum species cannot be overstated. Across China and Japan, it serves as a main or supplementary ingredient in over two thirds of traditional medications. For over 2000 years, it has been used to treat fevers, intestinal maladies, malaria, and countless other afflictions. Modern research indicates that it may possess...
