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Lysosomal Storage Disorders: A Practical Guide
Lysosomal Storage Disorders: A Practical Guide

Awareness of lysomal storage disorders needs to be raised and there is very substantial pharmaceutical interest to do so. The disorders are often viewed as obscurities but in fact they are treatable. Enzyme replacement therapy is available for four of the disorders and will be available for a further three disorders in the course of the next...

Dictionary of DNA and Genome Technology
Dictionary of DNA and Genome Technology

DNA technology is evolving rapidly, with new methods and a fast-growing vocabulary. This unique dictionary offers current, detailed and accessible information on DNA technology to lecturers, researchers and students throughout the biomedical and related sciences.

The third edition is a major update, with over 3000 references from...

Principles of Bone Regeneration
Principles of Bone Regeneration

Principles of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the study and treatment of bone healing in its diverse forms and under varying...

Enzyme Engineering: Methods and Protocols (Methods in Molecular Biology)
Enzyme Engineering: Methods and Protocols (Methods in Molecular Biology)

Whether the pursuit is commercially motivated or purely academic, engineering a novel biological catalyst is an enticing challenge. High-resolution protein structure analysis allows for rational alteration of enzyme function, yet many useful enzyme variants are the product of well-designed selection schemes or screening strategies. Enzyme...

Endosymbiosis
Endosymbiosis

The origin of energy-conserving organelles, the mitochondria of all aerobic eukaryotes and the plastids of plants and algae, is commonly thought to be the result of endosymbiosis, where a  primitive eukaryote engulfed a respiring α-proteobacterium or a phototrophic cyanobacterium, respectively. While present-day heterotrophic...

Controlled Genetic Manipulations (Neuromethods, Vol. 65)
Controlled Genetic Manipulations (Neuromethods, Vol. 65)

The current demand for the development of techniques for controlled genetic manipulations is driven by the anatomical and physiological complexity of the brain and by the need for experimental models that can address this complexity through selective manipulation of defined components of the system: specific neuronal populations or selected...

Toxicology and Epigenetics
Toxicology and Epigenetics

Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can...

The Compatibility Gene: How Our Bodies Fight Disease, Attract Others, and Define Our Selves
The Compatibility Gene: How Our Bodies Fight Disease, Attract Others, and Define Our Selves

This is the story of a few human genes and how we discovered what these genes do. We each have around 25,000 genes, but the genes in this story are those that vary the most from person to person. These genes--called compatibility genes--are, in effect, a molecular signature that distinguishes each of us as individuals. Davis tells the...

OPLL: Ossification of the Posterior Longitudinal Ligament
OPLL: Ossification of the Posterior Longitudinal Ligament
Ossifi cation of the posterior longitudinal ligament (OPLL) is no longer only a Japanese disease. In 2004, 18 papers on OPLL and related conditions were published, and 7 of those were from countries other than Japan. Major textbooks on spine surgery, such as The Spine, The Cervical Spine, and Spine Surgery, have devoted chapters to...
Polyadenylation: Methods and Protocols (Methods in Molecular Biology)
Polyadenylation: Methods and Protocols (Methods in Molecular Biology)

In Polyadenylation: Methods and Protocols, expert researchers in the field detail many of the protocols which are now commonly used to study polyadenylation. Focusing on recent advances in the fast-moving polyadenylation filed, that has recently been recognized as a key contributor to the complexity of mammalian gene expression....

Matrix Computations (Johns Hopkins Studies in the Mathematical Sciences)
Matrix Computations (Johns Hopkins Studies in the Mathematical Sciences)

The fourth edition of Gene H. Golub and Charles F. Van Loan's classic is an essential reference for computational scientists and engineers in addition to researchers in the numerical linear algebra community. Anyone whose work requires the solution to a matrix problem and an appreciation of its mathematical properties will find this book...

Biomarkers in Breast Cancer (Cancer Drug Discovery and Development)
Biomarkers in Breast Cancer (Cancer Drug Discovery and Development)

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the...

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