In the last decade, the delineation of the human genome and the development of high throughput genomics and proteomics have transformed the practice of Pediatrics. The study of normal childhood growth and development, and pediatric diseases now focuses on the delineation of normal and abnormal gene expression, resultant cellular and organ...

Recognized experts comprehensively review the clinical, surgical, radiological, and scientific aspects of atherosclerotic peripheral arterial disease (PAD), including endovascular, gene, and drug therapies. In their far-ranging discussions, the authors examine in depth the risk factors and antiplatelet therapies for PAD patients at high risk...

Cells respond to environmental cues through a complex and dynamic network of signaling pathways that normally maintain a critical balance between cellular proliferation, differentiation, senescence, and death. One current research challenge is to identify those aberrations in signal transd- tion that directly contribute to a loss of this...

12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are,...

A collection of both well-established and cutting-edge methods for investigating breast cancer biology not only in the laboratory, but also in clinical settings. These readily reproducible techniques solve a variety of problems, ranging from how to collect, store, and prepare human breast tumor samples for analysis, to analyzing cells in vivo...

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the...

 Attention deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder affecting 5–10% of children and adolescents and 3% of adults. Attention Deficit Hyperactivity Disorder: From Genes to Patients aims to provide a comprehensive, state-of-the-art overview of the critical aspects of ADHD, and hopefully will serve as...

A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection...

Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially...

The book that shows how to get the job done and deliver results . . . whether you’re running an entire company or in your first management job

Larry Bossidy is one of the world’s most acclaimed CEOs, a man with few peers who has a track record for delivering results. Ram Charan is a legendary advisor to senior...

In the last decade, the delineation of the human genome and the development of high throughput genomics and proteomics have transformed the practice of Pediatrics. The study of normal childhood growth and development, and pediatric diseases now focuses on the delineation of normal and abnormal gene expression, resultant cellular and organ...