Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl-...
At a meeting in Moscow in June 2005, Gil Strang suggested that there be a collection of Gene Golub's work to highlight his many important contributions to numerical analysis. The three of us were honored to undertake this pleasant task, with publication timed for February "29", 2007, the 75th anniversary of Gene's birth.
A collection of both well-established and cutting-edge methods for investigating breast cancer biology not only in the laboratory, but also in clinical settings. These readily reproducible techniques solve a variety of problems, ranging from how to collect, store, and prepare human breast tumor samples for analysis, to analyzing cells in vivo...
The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the...
Preimplantation genetic diagnosis (PGD) is a key technique in modern reproductive medicine. Originally developed to help couples who were at risk of transmitting single-gene genetic abnormalities to their children, the development of the FISH technique broadened chromosome analysis to include detection of more complex inherited abnormalities....
Discusses how gene therapy works, what diseases may be treated by it, what the moral and ethical issues are, and provides case studies of Ashi DeSilva and Jesse Gelsinger.
It was with great pleasure that I accepted the invitation of Springer to edit
this book.My association with the vascular endothelium covers a large part of
my scientific career and, as with any good long-standing relationship, it has
had moments of great excitement and periods of laborious construction. It
has sometimes been...
Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we’ve seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to...
A Fruitful Field for Researching Data Mining Methodology and for Solving Real-Life Problems Contrast Data Mining: Concepts, Algorithms, and Applications collects recent results from this specialized area of data mining that have previously been scattered in the literature, making them more accessible to...
Applications of Biotechnology in Oncology collects key writings by Kewal K. Jain on the most important contributions of biotechnology to cancer research, particularly to the molecular diagnosis of cancer and drug delivery in cancer for personalized management of patients. Basics of various “omics” technologies and their...
ParCo2007 marks a quarter of a century of the international conferences on parallel computing that started in Berlin in 1983. The aim of the conference is to give an overview of the state-of-the-art of the developments, applications and future trends in high performance computing for all platforms. The conference addresses all aspects of...
In the past, many tumor marker laboratory tests have not been sensitive enough for the very early detection of cancer. However, many of them have nonetheless proved useful in monitoring therapy, following the course of the tumor, and predicting prog nosis. Today, cancer may be viewed as a genetic disease with various specific chromo...
