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DNA Repair in Cancer Therapy (Cancer Drug Discovery and Development)
DNA Repair in Cancer Therapy (Cancer Drug Discovery and Development)
The field of DNA repair has been the subject of increasing interest at both the genetic and biochemical levels, leading to impressive progress in this area. DNA repair and its associated regulatory mechanisms lie at the heart of almost every fundamental aspect of cell biology, including transcription, cell cycle, apoptosis, and...
Minimally Invasive Neurosurgery
Minimally Invasive Neurosurgery

Recognized clinical leaders in neurosurgery and neuroradiology review the cutting-edge techniques and technologies now available and describe how minimally invasive techniques have influenced their subspecialties. On the radiology side, the authors explain the latest developments in magnetic resonance spectroscopy, functional imaging, and...

Microarrays in Clinical Diagnostics (Methods in Molecular Medicine)
Microarrays in Clinical Diagnostics (Methods in Molecular Medicine)
Within the last decade, microarray technology has evolved from an emerging technology developed and used by a few laboratories into a well-established technology used in laboratories all over the world. In fact, the need to characterize genetic alterations is one of the highest priorities for the future of medicine and the...
The Vascular Endothelium I (Handbook of Experimental Pharmacology) (v. 1)
The Vascular Endothelium I (Handbook of Experimental Pharmacology) (v. 1)
It was with great pleasure that I accepted the invitation of Springer to edit this book.My association with the vascular endothelium covers a large part of my scientific career and, as with any good long-standing relationship, it has had moments of great excitement and periods of laborious construction. It has sometimes been...
Handbook of Transcription Factor NF-kappaB
Handbook of Transcription Factor NF-kappaB

Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB...

Streptomyces in Nature and Medicine: The Antibiotic Makers
Streptomyces in Nature and Medicine: The Antibiotic Makers

This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth...

Macrophages: A Practical Approach
Macrophages: A Practical Approach

Macrophages are an important part of the immune response and are characterized by their ability to phagocytose foreign matter. However the difficulties involved in macrophage isolation mean they are some of the body's least explored cells. Macrophage Methodology describes how to isolate moderate to high yields of viable cells...

Diseases of the Liver & Biliary System
Diseases of the Liver & Biliary System
The eleventh edition welcomes the new Millenium. Progress in basic and clinical hepatology remains exponential. Since 1997, the advances have been wideranging, with those in molecular and cellular biology, and in diagnosis and treatment, leading the way. In a world in which information technology gives all too ready...
Genetics in Ophthalmology (Developments in Ophthalmology) (v. 37)
Genetics in Ophthalmology (Developments in Ophthalmology) (v. 37)

The objective of this publication is to enhance mutual understanding and communication between ophthalmologists, molecular geneticists, genetic counselors and biomedical researchers. In the introductory chapter, current genetic paradigms and experimental genetic approaches relevant to the nature of hereditary disorders are discussed. The...

Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics (Ophthalmology Research)
Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics (Ophthalmology Research)
Angiogenesis is of fundamental importance in development, health, and disease. The study of angiogenesis in the eye, in particular, has increased exponentially in the last decade because retinal and choroidal neovascularization play an important role in the major blinding diseases of the industrialized world and represent an...
Cancer Drug Resistance (Cancer Drug Discovery and Development)
Cancer Drug Resistance (Cancer Drug Discovery and Development)

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport,...

Intracranial Tumors: Diagnosis and Treatment
Intracranial Tumors: Diagnosis and Treatment

Brain tumors have a longstanding reputation for being intractable to therapy, and with evidence suggesting that the incidence of some brain tumors is increasing, this has become the most feared cancer. However, with improvements in imaging technologies, radiation therapy and chemotherapy , as well as a greater knowledge of the genetic causes...

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