The objective of this publication is to enhance mutual understanding and communication between ophthalmologists, molecular geneticists, genetic counselors and biomedical researchers. In the introductory chapter, current genetic paradigms and experimental genetic approaches relevant to the nature of hereditary disorders are discussed. The...

Macrophages are an important part of the immune response and are characterized by their ability to phagocytose foreign matter. However the difficulties involved in macrophage isolation mean they are some of the body's least explored cells. Macrophage Methodology describes how to isolate moderate to high yields of viable cells...

This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth...

Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB...

An ontology is a set of vocabulary terms with explicitly stated meanings and relations with other terms. Presently, a growing number of ontologies are being built and used for annotating data in biomedical research. Thanks to the tremendous amount of data being generated, ontologies are now being used in numerous ways, including connecting...

Preface.- List of contributors.- 1Informatics for Infectious Disease Research and Control.- 2 Bioinformatics of Microbial Sequences.- 3 Mining Databases for Microbial Gene Sequences.- 4 Comparative Genomics of...

The human genome is a well known symbol of scientific and technological progress in the 21st century. However, concerns about the exacerbation of inequalities between the rich and the poor, the developing and the developed states, the healthy and the unhealthy are causing problems for the progress of scientific research. The international...

Preimplantation genetic diagnosis (PGD) is a key technique in modern reproductive medicine. Originally developed to help couples who were at risk of transmitting single-gene genetic abnormalities to their children, the development of the FISH technique broadened chromosome analysis to include detection of more complex inherited abnormalities....

Neuroimmunology is one of the most rapidly developing branches of Neurobiology, prompted by novel neurochemical, neuroendocrinological, and neurophysiological investigations of the central and peripheral nervous system including neuroendocrine systems. Neuroimmunology can be considered as an interdisciplinary science that covers relevant...

This book discusses the principles and practice of breast cancer management within the context of multidisciplinary team working and places emphasis on pragmatism. The text provides a comprehensive and contemporary account of the subject and should permit the reader to develop a firm understanding of the disease from epidemiology, genetics...