Otosclerosis is a disorder causing a hardening of the middle ear bones which leads to a progressive hearing loss. Internationally renowned experts met in Saas Fee (Switzerland) in 2004 to discuss otosclerosis and stapes surgery, and they have subsequently been invited by the editor to present their findings in this publication. From basic to...

Experiments in the Purification and Characterization of Enzymes: A Laboratory Manual provides students with a working knowledge of the fundamental and advanced techniques of experimental biochemistry. Included are instructions and experiments that involve purification and characterization of enzymes from various source materials,...

The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.)...

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics...

Plasma and serum are the preferred non-invasive specimens to test normal individuals, at-risk groups, and patients for protein biomarkers discovered and validated...

Advances in molecular and genetics-based diagnostics are driving an increased interest in cytopathology, as cytological specimens are the ideal substrate for this new technology. Although there are a handful of comprehensive, standard texts on the market, there is a need for portable, more concise books for easy reference. Thus, the inception...

Considering the impact of translational breakthroughs on the early detection, diagnosis, prevention, and treatment of breast cancer, this all-encompassing guide collects cutting-edge research on the most promising strategies and agents likely to impact the management and long-term outcomes of women with breast cancer. This book will provide...

In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond...

High Performance Parallelism Pearls Volume 2 offers another set of examples that demonstrate how to leverage parallelism. Similar to Volume 1, the techniques included here explain how to use processors and coprocessors with the same programming – illustrating the most effective ways to combine Xeon Phi coprocessors with Xeon and...

Volumes are organized topically and...