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CRISPR Guide RNA Design: Methods and Protocols (Methods in Molecular Biology, 2162)
CRISPR Guide RNA Design: Methods and Protocols (Methods in Molecular Biology, 2162)
This detailed volume focuses on the CRISPR-associated guide RNA and how it can be designed, modified, and validated for a broad repertoire of purposes. Beginning with a section on computational design of target-specific guide RNAs, the book continues by covering chemical modifications to alter guide RNA stability, specificity, and...
Molecular Diagnostics: Fundamentals, Methods and Clinical Applications
Molecular Diagnostics: Fundamentals, Methods and Clinical Applications

The first text on molecular diagnostics specifically designed to educate students in clinical laboratory science programs! The authors have combined their knowledge and experience as educators to bring you the book you and your students have been asking for.

This exceptional new resource introduces the fundamentals...

Imaging of Soft Tissue Tumors
Imaging of Soft Tissue Tumors

This richly illustrated book provides a comprehensive survey of the growing role of medical imaging studies in the detection, staging, grading, tissue characterization, and post-treatment follow-up of soft tissue tumors. For each tumor group, imaging findings are correlated with clinical, epidemiologic, and histologic data. The relative...

Medical Image Analysis
Medical Image Analysis

The expanded and revised edition will split Chapter 4 to include more details and examples in FMRI, DTI, and DWI for MR image modalities. The book will also expand ultrasound imaging to 3-D dynamic contrast ultrasound imaging in a separate chapter.

A new chapter on Optical Imaging Modalities elaborating microscopy, confocal...

Color Atlas of Genetics, Third Edition (Flexibook)
Color Atlas of Genetics, Third Edition (Flexibook)

A remarkable achievement by a single author ... concise but informative ... No geneticist or physician interested in genetic diseases should be without a copy of this remarkable edition. --American Journal of Medical Genetics

More than ever, a solid understanding of genetics is a fundamental element of all medical...

RNA Editing: Methods and Protocols (Methods in Molecular Biology, 2181)
RNA Editing: Methods and Protocols (Methods in Molecular Biology, 2181)

This volume provides an overview about main RNA editing mechanisms, focusing on their functions in physiological as well as pathological conditions. Chapters guide readers through state- of-the art methodologies to investigate RNA editing through wet and dry approaches. Written in the highly successful Methods in Molecular Biology...

Detection of Cell Death Mechanisms: Methods and Protocols (Methods in Molecular Biology, 2255)
Detection of Cell Death Mechanisms: Methods and Protocols (Methods in Molecular Biology, 2255)

This volume provides detailed protocols for the performance, analysis, and troubleshooting of in vitro and in vivo experiments related to programmed cell death. Chapters compile conventional techniques such as western blot and qPCR and state-of-the art transmission electron microscopy and...

Osteoarthritis: Diagnosis and Medical / Surgical Management
Osteoarthritis: Diagnosis and Medical / Surgical Management
Written by the foremost experts, this text is a comprehensive clinical reference on osteoarthritis. Chapters review current information on the epidemiology, etiopathogenesis, and pathology of osteoarthritis, the biochemistry and molecular and cell biology of articular cartilage, and experimental models of osteoarthritis. Major sections focus on...
DNA Damage Recognition
DNA Damage Recognition

Stands as the most comprehensive guide to the subject―covering every essential topic related to DNA damage identification and repair.

Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular...

Patch Clamp Electrophysiology: Methods and Protocols (Methods in Molecular Biology, 2188)
Patch Clamp Electrophysiology: Methods and Protocols (Methods in Molecular Biology, 2188)

This volume describes a range of standard and novel methodological approaches used to probe ion channel function across different modalities. Chapters guide readers through methods and protocols from an introduction to the decades old patch clamp method for the ion channel neophyte to more complex, recent protocol advances, such as...

Prediction of Protein Structures, Functions, and Interactions
Prediction of Protein Structures, Functions, and Interactions

The growing flood of new experimental data generated by genome sequencing has provided an impetus for the development of automated methods for predicting the functions of proteins that have been deduced by sequence analysis and lack experimental characterization.

Prediction of Protein Structures, Functions and Interactions presents...

Computational Chemistry: Reviews of Current Trends (Computational Chemistry: Reviews of Current Trends, Vol 6)
Computational Chemistry: Reviews of Current Trends (Computational Chemistry: Reviews of Current Trends, Vol 6)

There are strong indications that, in the 21st century, computational chemistry will be a prime research tool not only for the basic sciences but also for the life and materials sciences. Recent developments in nanotechnology allow us to detect a layer of single atoms. Researchers are able not only to image but also to manipulate molecules...

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